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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10320 | Androgen receptor antagonist 1 | Others | |
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP... | |||
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | |||
T6509 | Galeterone | VN-124-1,TOK-001,VN/124-1,VN 124 | P450 , Androgen Receptor |
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a... | |||
T20625 | Prochloraz | Sporgon,Prelude | Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal |
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... | |||
T9179 | CLP-3094 | 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE | Androgen Receptor |
CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP... | |||
T13273 | UT-34 | Androgen Receptor | |
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost... | |||
T83119 | Androgen receptor antagonist 9 | Androgen Receptor | |
Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1]. | |||
T60987 | Androgen receptor antagonist 3 | ||
Androgen receptor antagonist 3 (Compound C18) has anticancer activities that is an antagonist of androgen receptor (AR) (IC 50 = 2.4 μM) [1]. | |||
T60988 | Androgen receptor antagonist 4 | ||
Androgen receptor antagonist 4 (Compound AT2) has anticancer activities. Androgen receptor antagonist 4 potently antagonizes the activity of AR transcriptional, inhibits downstream target gene of AR, and blocks the DHT-i... | |||
T75702 | Galloylalbiflorin | ||
Galloylalbiflorin (6′-O-Galloylalbiflorin), an androgen receptor (AR) antagonist with an IC50 value of 53.3 μM, is a compound isolated from the roots of Paeonia lactiflora. It exhibits anti-androgen activity [1]. | |||
T60719 | AR antagonist 3 | ||
When administered intratumorally, AR antagonist 3 shows effective inhibition on the growth of tumor. AR antagonist 3 is a potent and selective antagonist of androgen receptor (AR) with an IC 50 of 0.47 μM. AR antagonist ... | |||
T78945 | WCA-814 | Androgen Receptor | |
WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in prostatic cancer cells with half maximal inhibitory concentratio... | |||
T79465 | Anticancer agent 135 | Androgen Receptor | |
Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 heterodimerization to suppress downstream gene transcription. ... | |||
T78811 | PROTAC AR-NTD degrader 1 | Androgen Receptor | |
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antago... | |||
T35855 | AAA | ||
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-... |